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The side effects seen with orlistat are related to the reduced absorption of fat from your diet. Gastrointestinal (GI) side effects may last for less than one week, but have occurred for up to 6 months or longer. Maintaining an appropriate diet can help decrease side effects. The use of orlistat for greater than 2 years has not been studied. Side effects that you should report to your prescriber or health care professional as soon as possible:

• arthritis or joint pain/tenderness
• back pain
• rash, itching, or shortness of breath
• severe stomach pain
• yellow color appearing in your skin or the whites of your eyes
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Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

• stomach discomfort
• increased number of bowel movements
• loss of control of bowel movements
• urgent need to go to the bathroom
• gas with release of stool
• oily/fatty stools
• oily discharge
• clear, orange or brown colored bowel movements

This list may not describe all possible side effects.

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